Symbol Name ID |
En1
engrailed 1 MGI:95389 |
* | Aspects of the system are reported to show a normal phenotype. |
! | Indicates phenotype varies with strain background. |
Darker colors indicate more annotations |
Human Phenotypes | Hyposmia |
Spasticity |
Bradykinesia |
Tremor |
Depression |
Anxiety |
Panic attack |
Hallucinations |
Apathy |
Reduced social reciprocity |
Impulsivity |
Agitation |
Restless legs |
Cognitive impairment |
Dementia |
Frontal lobe dementia |
Short attention span |
Insomnia |
Hyperreflexia |
Dyskinesia |
Dystonia |
Gait imbalance |
Postural instability |
Abnormal autonomic nervous system physiology |
Disease(s) Associated with EN1 | ||||||||||||||||||||||||
Parkinson's disease |
Mouse Phenotypes | nervous system phenotype |
abnormal brain vasculature morphology |
abnormal neuron differentiation |
abnormal axon guidance |
decreased rhombomere 1 size |
microgliosis |
abnormal brain morphology |
abnormal brain development |
abnormal cerebellum development |
abnormal cerebellar lobule formation |
abnormal midbrain development |
decreased midbrain size |
abnormal choroid plexus morphology |
abnormal brain commissure morphology |
abnormal corpora quadrigemina morphology |
abnormal inferior colliculus morphology |
absent inferior colliculus |
decreased inferior colliculus size |
increased inferior colliculus size |
decreased superior colliculus size |
increased superior colliculus size |
abnormal hindbrain morphology |
abnormal cerebellum morphology |
abnormal cerebellum anterior vermis morphology |
decreased anterior vermis size |
absent cerebellar lobules |
abnormal cerebellum posterior vermis morphology |
abnormal cerebellum vermis morphology |
absent cerebellum |
astrocytosis |
abnormal innervation |
abnormal neuron morphology |
abnormal dopaminergic neuron morphology |
decreased dopaminergic neuron number |
ectopic dopaminergic neuron |
decreased neuron number |
abnormal serotonergic neuron morphology |
abnormal synapse morphology |
neuron degeneration |
abnormal cranial nerve morphology |
absent oculomotor nerve |
absent trochlear nerve |
neurodegeneration |
axon degeneration |
axonal dystrophy |
axonal spheroids |
abnormal CNS synaptic transmission |
abnormal synaptic dopamine release |
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Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||
En1tm1(Wnt1)Wrst/En1tm1(Wnt1)Wrst | |||||||||||||||||||||||||||||||||||||||||||||||||
En1tm1Alj/En1tm1Alj | ! | ! | ! | ! | |||||||||||||||||||||||||||||||||||||||||||||
En1tm1Alj/En1tm1Alj Tg(Wnt1-En1)1Amc/0 |
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En1tm1Gld/En1tm1Gld | |||||||||||||||||||||||||||||||||||||||||||||||||
En1tm2(cre)Gld/En1tm2(cre)Gld | |||||||||||||||||||||||||||||||||||||||||||||||||
En1tm2Alj/En1tm2Alj | |||||||||||||||||||||||||||||||||||||||||||||||||
En1tm4(en)Alj/En1tm4(en)Alj | |||||||||||||||||||||||||||||||||||||||||||||||||
En1tm5(en)Alj/En1tm5(en)Alj | * | ||||||||||||||||||||||||||||||||||||||||||||||||
En1tm1(Otx2)Wrst/En1+ | |||||||||||||||||||||||||||||||||||||||||||||||||
En1tm1(PDGFB)Nist/En1+ | |||||||||||||||||||||||||||||||||||||||||||||||||
En1tm1(Wnt1)Wrst/En1+ | |||||||||||||||||||||||||||||||||||||||||||||||||
En1tm2Alj/En1+ | * | ||||||||||||||||||||||||||||||||||||||||||||||||
En1tm2Alj/En1+ Tg(Th-EGFP)6-7Okn/? |
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En1tm1(Tnf)Fpit/En1tm1(Tnf)Fpit (conditional) | * | ||||||||||||||||||||||||||||||||||||||||||||||||
En1tm2(cre)Wrst/En1tm8.1Alj (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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